What lupus nephritis diagnosis should pay attention to? Lupus nephritis,
systemic lupus erythematosus refers to different pathological types of
autoimmune kidney damage, kidney damage accompanied by significant clinical
manifestation of a disease, systemic lupus erythematosus lupus nephritis
involving the kidneys caused by an immune complex glomerulonephritis, SLE is a
major cause of death and major complications.
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Pathology of lupus nephritis prognosis and therapy of the main basis. Reflect
disease activity indicators: severe mesangial and endothelial cell
proliferation, with or without granulocyte infiltration; nuclear debris; immune
complex deposition lot subendothelial; transparent thrombosis; glomerular
basement membrane rupture; cell or fibrous cellular crescents; capillary loops
fibrinoid necrosis. Where the latter is more important. The indicators reflect
chronic lesions: glomerulosclerosis; fibrous crescent; tubular atrophy;
interstitial fibrosis.
1. systemic manifestations: intermittent fever; malar erythema, as shaped
like a butterfly, also known as butterfly erythema; painless oral ulcers; a
plurality of joint pain; epilepsy or mental disorders; pale hand, foot and cold,
warm after turned purple, followed by restoration regular color, also known as
Raynaud's phenomenon.
2. Renal manifestations: isolated hematuria or proteinuria; hematuria,
proteinuria associated with edema, backache or hypertension, nephritis-like
performance namely; proteinuria, hypoalbuminemia, edema, nephrotic syndrome-like
performance namely; hematuria, protein Urine with a sharp decline in renal
function, performance was rapidly progressive glomerulonephritis; chronic renal
failure performance. Life can be expressed as one of the cases.
3. laboratory abnormalities: blood leukopenia, or anemia, or
thrombocytopenia; ESR; Complement C3 low; antinuclear antibodies and
autoantibodies. Biopsy only help diagnose lupus nephritis, a serious kidney
damage more clearly the extent, help to determine the condition and proper
treatment.
More common in young women who are asymptomatic mild hematuria without
proteinuria or edema associated with hypertension, but the majority of cases may
have proteinuria red white catheter urine. Rapid onset of a few cases, renal
function deteriorated rapidly, most patients with renal involvement arthritis
rash etc. renal manifestations occur. Severe cases involving the serous lung
disease often quickly hepatic blood-forming organs and other organs and tissues,
and with appropriate clinical manifestations. Approximately 1/4 of the patients
with kidney damage as the first performance, for women of childbearing age have
kidney disease should be a routine examination and serological indicators
related to the disease.
How to diagnose: Physical examination revealed acute phase of fever is more
common; most patients with anemia; facial butterfly erythema of the changes may
be associated with hair loss, rash, swelling of joints heart murmur or
pericardial effusion hepatosplenomegaly lymphadenopathy, and varying degrees of
edema or hydrothorax so the symptoms.
Physical examination revealed acute phase of fever is more common; most
patients with anemia; facial butterfly erythema of the changes. It can be
accompanied by joint swelling, hair loss, rash, heart murmur or pericardial
effusion, hepatosplenomegaly, lymphadenopathy, and varying degrees of symptoms
of edema or ascites and pleural effusion, etc.