Under physiological conditions, the glomerular capillary wall can effectively prevent macromolecular materials such as blood proteins and red blood cells into the capsules renales.Mientras pathological condition is low, the filtration barrier is damaged and there will be glomerular proteinuria.
NS pathogenic factors include immune system, environment, inheritance etc.Among which the immune factor is the main factor inducing humoral immune including cellular immune and immune mechanism in which the intrinsic kidney cells are involved.
Before the invention of antibiotics, infection is a major cause of death NS.Los risks of illness and death have been greatly reduced with the understanding NS and its complications.
Cyclosporin has a dual function in treatment of nephrotic syndrome.
1.The inmunológico.Cyclosporin mechanism can inhibit the activation of IL-2 and T lymphocytes selectively and reversibly (immune reaction is mediated by T cells in the pathogenesis of NS).
2.Mecanismo not inmunológico.Puede help reduce proteinuria by influencing the glomerular permeability including opening selectivity, charge selectivity and glomerular filtration rate (GFR).
The structure and function of the podocytes is very crucial to maintaining the normal function of glomerular.Sinaptopodina filtration barrier is a major skeleton podocitos.Cyclosporin proteins can help reduce degradation and maintain stability and reduce podocyte damage.
It has been shown that Cycloporin is effective in alleviating proteinuria and inflammation and is a very necessary for conditions of severe illness immunosuppressant, but the long-term consumption of cycloporin cause a lot of side effects such as moon face, hairiness susceptibility to infections, osteoporosis, necrosis of the femoral head etc.Therefore Therefore patients, especially children should not rely on cycloporin only.
