2017年5月31日星期三

Renal transplantation will recur

70% of uremia is developed by glomerulonephritis. And almost all glomerular nephritis developed into uremia, after renal transplantation may recur.

Spend so much money for the kidney, how will relapse?

Because the root of the kidney, not in the kidney.

For example, the normal kidneys, transplanted to the patient's body, the normal kidneys will get kidney disease.

In turn, the "kidney" transplanted to the normal body, the kidneys will be restored to health.

What are Symptoms of Focal Segmental Glomerulosclerosis (FSGS)

Visible, the root cause of kidney disease in your body, but not in the kidney. Nephropathy is a blood disease involving immunization, it is related to the whole body, a kidney disease patients only transplant kidney, then, is still kidney disease patients.

Is kidney transplant recurrence serious?

Do the kidney transplant patients do not have to worry too much, relapse is not surgery to do white, but let you back from the uremic period to the nephritis period.

Will Third Stage Of FSGS Make Me Tired

In other words, will go again [nephritis → kidney failure → uremia] this road.
Who is easy to relapse after transplantation?

Focal segmental glomerulosclerosis (FSGS), the possibility of recurrence is relatively high, about 50% .And, 40% to 50% of patients with recurrent grafts will be lost; so these patients are generally not recommended for kidney transplantation.

IgA nephropathy, renal transplant recurrence rate is very high. 80% of the transplanted kidney, into the recipient after the body will suffer from IgA nephropathy.

Crescentic nephritis, such patients is best to wait until the cycle of antibody down to undetectable, and then transplanted to reduce recurrence;

Lupus nephritis, transplant recurrence rate as high as 35%. It is noteworthy that patients with lupus ulcers prone to venous or arterial thrombosis, surgery should pay attention to check part of the prothrombin time, anticardiolipin antibodies and lupus anticoagulant;

Purpura nephritis, up to 75% of patients have relapse. Recurrence of high population, mainly in the 8 to 18 months before transplantation is still sick patients.

Active multiple myeloma with bone marrow infiltration, whole blood cell reduction in patients, prone to infection and bacteremia, such patients after the risk of recurrence after transplantation as high as 70%.

Reduce recurrence rate

Since the recurrence rate of kidney transplantation is so high, then we need to find ways to reduce the recurrence rate. There are two ways:

1. Use high-dose cyclosporine A;

2. do plasma exchange.

This can remove class I anti-HLA antibodies, successfully reduce the recurrence, both can be used at the same time.

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