First, the glomerular filtration membrane consists of three parts, namely, from the inside to the outside wall of the capillary endothelial cells, basement membrane and epithelial cells. Blood flow through the kidneys when the small molecules of toxic substances can leach out of the body, such as the protein macromolecules will be asked to stay down.
Second, the glomerular filtration membrane filtration principle is the same as actually just a sieve, drain the mouth is a fixed size, the ability to retain more than the molecular diameter smaller than the filtration, which belongs to the physical layer barrier. Further, the upper surface will be covered with a layer of filtration membrane proteins and the negatively charged sialic acid classes heparin sulphate, and protein in the body will also usually with a negative charge, so that due to the "A Negative rejection of 'principle can make proteins pass past.
Ultimately, the regulatory function monitors mesangial filtration mesangial ball, if the feedback showed doubt seize the time to go out, then the kidney filtration function will enhance the full foot needs.
Our kidney experts here explain it in details. This balance will be out of balance due to damaged kidney cells. Loss of function as part of the barrier, drain hole becomes larger and substances with a negative charge less, even if there tubules also totally failed in all of the protein reabsorbed back effect will allow patients with renal comprehensive exhibit proteinuria PRO's situation. The urinalysis and renal function tests can observe the changes in proteinuria.
