2015年8月12日星期三

What Should You Pay Attention to the Diagnosis of Lupus Nephritis

What lupus nephritis diagnosis should pay attention to? Lupus nephritis, systemic lupus erythematosus refers to different pathological types of autoimmune kidney damage, kidney damage accompanied by significant clinical manifestation of a disease, systemic lupus erythematosus lupus nephritis involving the kidneys caused by an immune complex glomerulonephritis, SLE is a major cause of death and major complications.

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Pathology of lupus nephritis prognosis and therapy of the main basis. Reflect disease activity indicators: severe mesangial and endothelial cell proliferation, with or without granulocyte infiltration; nuclear debris; immune complex deposition lot subendothelial; transparent thrombosis; glomerular basement membrane rupture; cell or fibrous cellular crescents; capillary loops fibrinoid necrosis. Where the latter is more important. The indicators reflect chronic lesions: glomerulosclerosis; fibrous crescent; tubular atrophy; interstitial fibrosis.

1. systemic manifestations: intermittent fever; malar erythema, as shaped like a butterfly, also known as butterfly erythema; painless oral ulcers; a plurality of joint pain; epilepsy or mental disorders; pale hand, foot and cold, warm after turned purple, followed by restoration regular color, also known as Raynaud's phenomenon.

2. Renal manifestations: isolated hematuria or proteinuria; hematuria, proteinuria associated with edema, backache or hypertension, nephritis-like performance namely; proteinuria, hypoalbuminemia, edema, nephrotic syndrome-like performance namely; hematuria, protein Urine with a sharp decline in renal function, performance was rapidly progressive glomerulonephritis; chronic renal failure performance. Life can be expressed as one of the cases.

3. laboratory abnormalities: blood leukopenia, or anemia, or thrombocytopenia; ESR; Complement C3 low; antinuclear antibodies and autoantibodies. Biopsy only help diagnose lupus nephritis, a serious kidney damage more clearly the extent, help to determine the condition and proper treatment.

More common in young women who are asymptomatic mild hematuria without proteinuria or edema associated with hypertension, but the majority of cases may have proteinuria red white catheter urine. Rapid onset of a few cases, renal function deteriorated rapidly, most patients with renal involvement arthritis rash etc. renal manifestations occur. Severe cases involving the serous lung disease often quickly hepatic blood-forming organs and other organs and tissues, and with appropriate clinical manifestations. Approximately 1/4 of the patients with kidney damage as the first performance, for women of childbearing age have kidney disease should be a routine examination and serological indicators related to the disease.

How to diagnose: Physical examination revealed acute phase of fever is more common; most patients with anemia; facial butterfly erythema of the changes may be associated with hair loss, rash, swelling of joints heart murmur or pericardial effusion hepatosplenomegaly lymphadenopathy, and varying degrees of edema or hydrothorax so the symptoms.


Physical examination revealed acute phase of fever is more common; most patients with anemia; facial butterfly erythema of the changes. It can be accompanied by joint swelling, hair loss, rash, heart murmur or pericardial effusion, hepatosplenomegaly, lymphadenopathy, and varying degrees of symptoms of edema or ascites and pleural effusion, etc.

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