Effect of uremic state of metabolism
Carbohydrate metabolism disorders
Uremic patients mildly elevated blood sugar, which increased with different
mechanisms of diabetes, diabetes is absolute or relative insulin secretion, and
hyperglycemia uremic patients mainly cells to insulin sensitivity decreased. A
certain amount of normal oral glucose, serum insulin increased accordingly; if
it is diabetes, which increased more significantly, suggesting the need for more
insulin than normal cells use glucose. According to reports, uremic patients
within the normal endogenous insulin secretion, ingestion of exogenous insulin
levels in the body to maintain higher than normal, due to the insulin in the
blood of uremic patients can be maintained for a longer period of time, chronic
diabetes, once After uremia, insulin dosage can be reduced.
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Protein metabolism
Protein metabolism of nitrogenous waste, since not ranked in vitro, in vivo
accumulation, blood urea nitrogen increased. Therefore, in the treatment of
uremia, generally limit the intake of protein, malnourished patients, patients
undergoing long-term hemodialysis, protein intake can be slightly relaxed some
restrictions, uremia abnormal levels of serum amino acids, some people Serum
concentrations of certain amino acids can be 2 to 3 times higher than normal. On
the other hand, serum essential amino acid content may be lower than normal
people, the lack of essential amino acids, for autologous tissue reconstruction
may be greatly affected.
Fat metabolism
Effect of uremia on fat metabolism has not been much research, it is known
most dialysis patients, increased serum triglycerides and free fatty acid
levels, blood cholesterol and phospholipids normal.