prognosis of IgA nephropathy mainly with, a large, impaired renal function, glomerulosclerosis, interstitial fibrosis and renal
arteriolar sclerosis about. Therefore, the treatment of IgA nephropathy should take individual grading treatment according to these
indicators are according to the degree of difference between treat.
Treatment principle: infection prevention and control; (2) to control blood pressure; (3) reduce urinary protein; fourthly, protect
renal function; fifthly, to avoid the use of exertion, and nephrotoxic drugs, and regular follow-up.
Commonly used treatment methods include: angiotensin angiotensin converting enzyme inhibitor (ACEI) and vascular nervous endothelin
receptor antagonist (ARB) and other antihypertensive drugs, corticosteroids and other immunosuppressive agents, anticoagulation and
antiplatelet aggregation and promote fibrinolytic drugs, including traditional Chinese medicine and tonsillectomy.
1 for the tonsil after infection in the naked eye or abnormal urine in patients with increased, active control of infection, early
tonsillectomy. Retrospective study showed that the effect of the removal of the patients with mild to moderate IgA nephropathy was
effective, which could reduce the incidence of proteinuria, hematuria and end stage renal failure.
2 for patients with normal blood pressure, normal renal function and urinary protein 1 h g/24, many foreign scholars believe that
there is no need for special treatment, only regular review. But we found that these patients should be combined with renal biopsy
pathology, to develop appropriate treatment options for active treatment, is conducive to patients with complete remission.
3 for urinary protein 1 h g/24 patients, the first choice of ACEI or (and) ARB, and strive to the urine protein to 0.5 h g/24 below.
If the use of adequate ACEI and ARB, blood pressure has been reduced to mmHg 125/75, urinary protein is still 1 h g/24 renal function
in normal patients, should be treated with glucocorticoid hormone therapy.
The use of hormones and other immunosuppressive agents, in addition to taking into account the volume of urine protein, but also to
consider the pathological changes in renal biopsy. Obvious inflammatory cell infiltration, cell proliferation, especially the
formation of the new moon is the application of hormone and other immune inhibitors to the indications. For patients with IgA
nephropathy complicated with minimal change nephrotic syndrome, according to the treatment of minimal change nephrotic syndrome.
4 for patients with IgA nephropathy associated with hypertension, and strive to lower the blood pressure to mmHg 130/80; if the urine
protein 1 h g/24, as far as possible to the blood pressure to mmHg 125/75. Commonly used antihypertensive drugs are ACEI, ARB, long
acting calcium antagonists, diuretics and blockers and receptor blockers.
5 for patients with IgA nephropathy, it is appropriate to first clear the reasons for renal insufficiency, for the reasons for
treatment. We treated patients with moderate to severe IgA nephropathy with obvious cell proliferation and fibrin deposition, treated
with ACEI combined with urokinase, and achieved good results in reducing proteinuria and delaying the deterioration of renal function.
