Causes
1. renal hemodynamic abnormalities: renal hemodynamic abnormalities play a key role in diabetic nephropathy. In addition if patients with hypertension diabetes, will significantly accelerate the development and progression of diabetic nephropathy.
2. glycation end product formation: Diabetic patients fail to control blood sugar, high blood sugar can lead to long-term glycation end product formation increased glycation end products can cause extracellular matrix, such as collagen type Ⅳ, so that patients glomerular synthesis of collagen type Ⅳ endothelial, mesangial and smooth muscle cell proliferation and induce diabetic nephropathy.
3. Genetic factors: Diabetic nephropathy has certain genetic factors, family history of diabetes in patients with essential hypertension incidence may increase the risk of kidney disease three times. And some long-term patients suffering from diabetes, even though the course is very long but also less prone to diabetic nephropathy, which can be seen, diabetic nephropathy and genetic have a certain relationship.
What is the treatment of diabetic nephropathy
1. Strict control of blood glucose: Early diabetes with insulin or multiple subcutaneous insulin strict control of diabetes, so to maintain normal blood sugar, can delay or even prevent the occurrence and development of diabetic nephropathy, reduce the increased glomerular filtration rate and improve trace albuminuria.
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2. Control Hypertension: high blood pressure in patients with renal failure will promote the development of effective antihypertensive therapy can slow the rate of decline in glomerular filtration rate, reduce urinary albumin excretion. Angiotensin-converting enzyme inhibitors or angiotensin Ⅱ receptor antagonist can be used as the drug of choice, and often need combined with other antihypertensive drugs. Other antihypertensive drugs such as calcium channel blockers, diuretics, β-blockers, methyldopa, clonidine and the like. Diabetic patients blood pressure should be controlled at 130 / 80mmHg or less.
3. Restrict protein intake: appropriate to reduce the amount of protein in the diet may reduce glomerular pressure, reduce high filtration and reduce proteinuria. And administering to the patient a high protein diet will increase the glomerular histological lesions, renal insufficiency has more protein intake should be limited, and should eat a high protein containing essential amino acids.
4. dialysis and kidney transplantation: the only effective way once diabetic nephropathy renal failure, dialysis and kidney transplantation.
Treatment need to be cautious, promptly get rid of diabetic nephropathy. We want to treat kidney disease optimistic in the face of our life only a good attitude, the body can quickly recover. In addition to timely treatment in life but also the lives of timely care, if you are still in doubt for the treatment of the disease, also can consult our online nephrologist.
